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RETINOBLASTOMA-LIKE PROTEIN P130
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DeCS
Descriptor
English
:
Retinoblastoma-Like Protein p130
Descriptor
Spanish
:
Proteína p130 Similar a la del Retinoblastoma
Descriptor
Portuguese
:
Proteína p130 Retinoblastoma-Like
Synonyms
English
:
RBL2 Protein
Retinoblastoma Like Protein p130
Retinoblastoma Like Protein 2
p130, Retinoblastoma-Like Protein
Retinoblastoma-Like Protein 2
Tree Number:
D12.776.624.776.735
D12.776.660.794
D12.776.744.755
Definition
English
:
A negative regulator of the
CELL CYCLE
that undergoes
PHOSPHORYLATION
by
CYCLIN-DEPENDENT KINASES
. RBL2 contains a conserved pocket region that binds
E2F4 TRANSCRIPTION FACTOR
and
E2F5 TRANSCRIPTION FACTOR
. RBL2 also interacts with viral ONCOPROTEINS such as
POLYOMAVIRUS
TUMOR
ANTIGENS
;
ADENOVIRUS E1A PROTEINS
; and
PAPILLOMAVIRUS E7 PROTEINS.
History Note
English
:
2006(1994)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
51163
Unique Identifier:
D050717
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS